IPS Brazil – Internacional Proteolysis Society – A Meeting an Proteases , their Substrates and Inhibitors in Health and Disease

OCTOBER, 26 - 30TH, 2025

Atlântico Convention and Resort

Búzios, Rio de Janeiro – Brazil

A MEETING ON PROTEASES , THEIR SUBSTRATES AND INHIBITORS IN HEALTH AND DISEASE

Blood Disorders and Hemostasis
Cancer
Cardiovascular disease
Drug Discovery
Immunity
Metabolism and Metabolic Disorders
Neurodegenerative Disorders and Ageing

New Tools to Study Proteolysis
Pathogens
Signaling
Skin and wounding
Structure – Function Relationship
Ubiquitination and Protein turnover

Hotel Atlântico Búzios

Estr. da Usina Velha, 294
Village de Búzios, Búzios
RJ – Brazil

Organization

Chair: Ana Paula Lima – Universidade Federal do Rio de Janeiro
Co-Chair: Maria Luiza Oliva – Universidade Federal de São Paulo

INTERNATIONAL
Scientific Committee

Anthony O’Donoghue
University of California in San Diego
Laura Edgington-Mitchell
University of Melbourne
Marcin Drag
Wroclaw University of Technology
Ruth Geiss-Friedlander
University of Freiburg
Thomas Reinheckel
University of Freiburg

LOCAL
Scientific Committee

Ana Marisa Chudzinski-Tavassi
Instituto Butantan
Heloisa Sobreiro Selistre de Araújo
Universidade Federal de São Carlos
Patrícia Maria Guedes Paiva
Universidade Federal de Pernambuco

Event of:

Sponsorship:

Organization support:

General Information

The International Proteolysis Society aims to promote knowledge on the role of proteolysis in all aspects of biological and biomedical research, assembling a wide audience of experts and promoting the training of young scientists in the field. The biennial Meeting of IPS brings together the global scientific community working on proteases, their substrates, and inhibitors, and is a must attend event since 1999.

Highlighted themes include: ageing, cancer, protein turnover and degradation, blood, immunity, infections, neurobiology, metabolism, therapeutic targets, structural biology and much more!

The conference will bring together researchers at various career stages and industry representatives across the field of proteolysis. The 5-day event will include the latest developments in basic and translational research involving proteases including cell biology, structure, biochemistry, new therapeutic approaches for human diseases and state of the art technologies.

IPS2025 will represent a key opportunity for interaction across borders and research fields to enhance knowledge in proteolysis in biological and biomedical sciences, providing exciting opportunities for international collaboration.

IPS2025 will be held in the coastal town of Armação dos Búzios, situated in the State of Rio de Janeiro, in Brazil, just 173 km from the international airport of the city of Rio de Janeiro. Búzios is a beautiful tourist village, located in the tropical zone of the South American subcontinent, bathed by the waters of the Atlantic Ocean, with 23 beaches.

VISA REQUIREMENTS: Brazil requires entry visas for citizens of Afghanistan, Algeria, Angola, Australia Bhutan, Cambodia, Canada, Chad, China, Comoros, Cuba, Democratic Republic of Congo, Djibouti, Egypt, Equatorial Guinea, Eritrea, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Haiti, Ivory Coast, India, Iraq, Iran, Jordan, Kazakhstan, Kenya, Kyrgyzstan, Laos, Lesotho, Liberia, Libya, Madagascar, Malawi, Maldives, Mali, Morocco, Mauritania, Mozambique, Nepal, Niger, Nigeria, North Korea, Oman, Pakistan, Republic of Congo, Rwanda, Saudi Arabia, Senegal, Sierra Leone, Somalia, Sri Lanka, Sudan, South Sudan, Taiwan, Tanzania, Togo, Uganda, United States of America, Uzbekistan, Vanuatu, Vietnam, Yemen, Zambia, Zimbabwe.

Please check if you require a visa at:
https://formulario-mre.serpro.gov.br/sci/pages/web/ui/#/servicos-estrangeiros

Be aware that visas may take a few weeks to be issued, so apply early. Note the change in Brazilian Law effective April 10th, 2025 that will also require US, Canadian and Australian citizens to apply for visas prior to entry.

If you need a letter for your visa application, please send a request with your full name to: ipsbrazil2025@gmail.com

We look forward to welcoming you to IPS2025 in Búzios!

CHECK LATER FOR UPDATES IN THE FULL PROGRAM

SCIENTIFIC PROGRAM

Sunday, October 26^th:

16:00h-18:00h – Registration

18:00h- 18:30h – Snacks and coffee

18:30h-18:55h – Welcome and Opening Ceremony (IPS 25^th anniversary) –

IPS Legacy 1999-2025

18:55h-19:00h – Chair: Christopher Overall – Introduction of Opening Lecture

19:00h-20:00h – Opening Lecture

Charles Craik, University of California in San Francisco, USA

Achieving the Potential of Conditionally Activated Therapeutics

20:00h-20:10h Sponsor hour: Instituto Butantan -São Paulo, Brazil

20:10h-22:10h – Welcome reception

Monday, October 27^th:

9:00h-9:05h – Chair: Ruth Geiss-Friedlander, University of Freiburg, Germany

9:05h-10:00h – Plenary lecture

Michael H. Glickman, Technion – Israel Institute of Technology, Haifa

The Proteasome – A Multi-Catalytic Protease

10:00-10:25h – Coffee Break

10:30h-11:45h – Session 1: Proteases in Neurobiology and Ageing

Chair: Eiichiro Nishi, Shiga University of Medical Science, Japan

10:30h-10:55h – Natalie Sims, St Vincent’s Institute Melbourne, Australia

Lysosomal proteases in the osteocyte network: controlling bone composition from within?

10:55h-11:20h – Taisuke Tomita, University of Tokyo, Japan

Enhanced proteolytic degradation of amyloids by photo-oxygenation as novel therapeutic strategy for neurodegenerative diseases

11:20h -11:45h – Dieter Bromme, University of British Columbia, Canada

The Cis/Transpeptidase Activity of Cathepsins: The missing link in understanding neoantigens in autoimmunity?

11:45h-12:00h – Oral presentation 1: Danieli Ferrari – University of British Columbia, Canada

Granzyme B deficiency enhances myelin repair and locomotor recovery after spinal cord injury

12:00h- 12:15h – Oral presentation 2: Jonathan Coene – Katholieke Universiteit Leuven, Belgium

Noval Legumain Activity-Based Probes

12:15h- 14:00h – Lunch

14:00h- 15:40h – Session 2: Targeting Proteolysis for Therapeutic Intervention

Chair: Marcin Drag, Wroclaw University of Science and Technology, Poland

14:00h-14:25h – Rama Khokha, University of Toronto, Canada

Title to be announced

14:25h-14:50h – Henry Maun, Genentech, USA

Complete inhibition of β–tryptase by tetramer dissociation and active site allostery due to a single antibody residue

14:50h-15:15h – Manuel Saldivia, Novartis, USA

Drugging the Degrader: Discovery of Parasite-Selective Proteasome Inhibitors

15:15h-15:30h – Oral presentation 3: David Granville – University of British Columbia, Canada

Multi-omic analyses reveals new roles for Granzyme K in psoriasis

15:30h-15:45h – Oral presentation 4: James W Janetka – Washington University, USA

Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1

15:45h-16:10h – Coffee break

16:15h-18:05h – Session 3: Structural Insights into Protease Function

Chair: Kvido Strisovsky, Institute of Organic Chemistry and Biochemistry, Czech Republic

16:15h – 16:40h – Joanne Lemieux, University of Alberta, Canada

Protease-targeted inhibition to address the global AMR threat in gram-negative pathogens

16:40h -17:05h – Hans Brandstetter, University of Salzburg, Austria

Exciting exosites: principles of allosteric activity tuning in cysteine and metalloproteases

17:05 h -17:30h – Jonas Emsley, University of Nottingham, UK

Decoding Contact System Assembly: Structural Mechanisms of Protease Activation and Regulation

17:30h – 17:45h – Oral presentation 5: Irina Bezsonova – Dana Farber Cancer Institute, USA

Unlocking the Puzzle: NMR Spectroscopy Unravels the Mechanism of USP7 Auto-Regulation

17:45h – 18:00h – Oral presentation 6: Jan Konvalinka – Institute of Biotechnology, Czech Republic

Structural characterization of peptidomimetics targeting fibroblast activation protein

18:00-19:30h – Poster Session 1

Tuesday, October 28^th:

9:00h-9:05h – Chair: Catherine Moali, CNRS, France

9:05h-10:00h – Plenary Lecture

Irit Sagi, The Weizmann Institute of Science, Israel

Long-Lived Nascent proteolytic ECM Damage Imprints (EDI) impact Tissue Regeneration and Perpetuate Chronic Disease

10:00-10:25h – Coffee Break

10:30h-11:45h – Session 4: Proteolysis in Cellular Homeostasis and Cancer

Chair: Klaudia Brix, Constructor University, Germany

10:30h-10:55h – William W Bachovchin, Tufts University, USA

Determinants of optimal precision targeting of chemotherapeutics to tumors using FAP-activated prodrugs

10:55h-11:20h – Thomas Reinheckel, University of Freiburg, Germany

Functional and molecular links between methionine aminopeptidase 1 (Metap1) and the oncogenic PI3K-pathway in breast cancer

11:20h-11:35h – Oral presentation 7: Nabil G. Seidah –IRCM, Canada

The complementary and synergistic roles of the proprotein convertases PCSK7 and PCSK9 in health and disease

11:20h-11:50h – Oral presentation 8: Lisa Munter – McGill University, Canada

Depletion of the rhomboid protease RHBDL4 increases survival in a mouse model of breast cancer

11:50h-12:05h – Oral presentation 9: Samuel Zolg – University of Freiburg, Germany

An interplay between proteases: DPP9 as a regulator of non-lysosomal cathepsins

12:05h-12:20h – Oral presentation 10: Katiuchia U. Sales – University of São Paulo/Ribeirão Preto, Brazil

Exploring the KLK5–KLK14 Axis in Squamous Cell Carcinogenesis

12:15h-14:00h – Lunch

14:00h-15:15h – Session 5: Emerging Techniques in Proteolysis Research

Chair: Jan Kovalinka, Institute of Organic Chemistry and Biochemistry, Czech Republic

14:00h-14:25h – Anthony O’Donoghue, University of California in San Diego (UCSD), USA

Chemical Decoupling: A Novel Strategy for Functional Profiling of Individual Proteasome Subunits

14:25h-14:50h – Konstantinos Kalogeropoulos, Technical University of Denmark

End-to-end workflows for global analysis of protease activity

14:50h-15:15h – Galia Blum, The Hebrew University of Jerusalem, Israel

Novel cathepsin inhibitors for disease management

15:15h-15:30h – Margaux M. Pinney, University of California, Berkeley, USA

High-throughput mechanistic protease enzymology

15:30h-15:45h – Oral presentation 11: Wayne Denis Monteiro – Johns Hopkins University, USA

Protease Substrate Profiling using Molecular Indexing of Proteins by Self-Assembly

15:45h-16:10h – Coffee break

16:15h-18:00 h – Session 6: Proteolysis in Blood and Cardiac Function

Chair: Lakshmi Wijeyewickrema, La Trobe University Melbourne, Australia)

16:15h – 16:40h – Ze Zheng, Medical College of Wisconsin, USA

Novel functions of tPA in shaping plasma atherogenic lipid profile

16:40h -17:05h – Long-Sheng Song, University of Iowa, USA

Calpain-Mediated Proteolysis of Junctophilin-2 in Heart Failure

17:05 h -17:30h – Alvin Schmaier, Case Western University, USA

Bradykinin is a Proximal Cause of Cerebral Malaria

17:30h – 17:45h – Oral presentation 12: Antoine Dufour – University of Calgary, Canada

Multi-modal omics analysis to unravel the Proteolytic and Non-Proteolytic Roles of Calpain-3 in disease

17:45h – 18:00h – Oral presentation 13: Daniel Sojka – Biology Centre CAS, Czech Republic

Proteolytic Mechanisms in Ticks and Tick-Borne Pathogens: From Biological Insights to Druggable Targets

18:00-19:30h – Poster Session 2

Wednesday, October 29^th:

8:00h-9:30h – Special session: Pharmacological Inhibition of Cathepsin C (Dipeptidyl Peptidase 1) in Neutrophil-Mediated Diseases

Chair: Brice Kormaz, INSERM, France

8:00h-8:15h – Brice Korkmaz and Arianna Bordin, INSERM, France

Therapeutic targeting of cathepsin C: from pathophysiology to treatment

8:15h-8:30h – Lada Sabirova, INSERM, France

Consequences of cathepsin C inhibition on neutrophil serine proteases activation

8:30h-8:45h – Liu Baoer, University Hospital Halle (Saale), Germany

Pharmacological inhibition of cathepsin C in preclinical models

8:45h-9:10h – Kuan-Ju Chen, INSMED, USA

Exploring Cathepsin C (DPP1) Inhibition in Preclinical Models of Rheumatoid Arthritis

9:10h-9:35h – Patrick McDonald, INSMED, USA

Impact of CatC/DPP1 on neutrophil functional responses

09:35h-12:15h – Free Time (Boat tour 10:10h-11:40h – optional sign up)

12:15h-14:00h – Lunch

14:00h-15:40h – Session 7: Proteolysis in Cellular Physiology and Signalling

Chair: Gilles Lalmanach, Université François Rabelais, France

14:00h-14:25h – Mark Gorrell, University of Sidney, Australia

Roles of the prolyl oligopeptidases FAP, DPP4 and DPP9 in fibrosis and tumours

14:25h-14:50h – Catherine Moali, CNRS, France

The mini-collagen toolkit sheds new light on the activity of procollagen proteinases

14:50h-15:15h – Katarzyna Groborz – Wroclaw University, Poland

Exploring macrophage activation with a new generation of caspase probes: how much caspase does it take to kill a cell?

15:15h-15:30h – Oral presentation 14: Sabine Hoeppner – University of Augsburg, Germany

Low Cellular Carbohydrate-Levels Induce Expression of Signal-Peptide-Peptidase-Like 3 (SPPL3)

15:30h-15:45h – Oral presentation 15: Fabio Melo – Uppsala University, Sweden

Mast cell tryptase induces nuclear remodeling and reduced growth in breast cancer cells

15:45h-16:10h – Coffee break

16:15h-17:35 h – Session 8: Proteolysis in Immunity

Chair: Antoine Dufour, University of Calgary, Canada

16:15h – 16:40h – Chris Overall, University of British Columbia, Canada

Unconventional Secretion and Activity of SARS-CoV-2 Main Protease (3CLpro) by Caspase and 3CL^pro Activation of Gasdermin D Pore Formation

16:40h -17:05h – Natalie Vergnolle, INSERM, France

Mucosal proteases: targets for visceral pain control

17:05 h -17:30h – Nathan Archer, The Johns Hopkins University, USA

Proteases in the progression of the atopic march

17:30h – 17:45h – Oral presentation 16: Marcin Poreba – Wroclaw University, Poland

Development of Protease-Selective Antibody–Drug Conjugates via Peptide Linkers Containing Unnatural Amino Acids

17:45h – 18:00h – Oral presentation 17: Alina Lozan – University of Freiburg, Germany

Differential impact of cytosolic dipeptidyl aminopeptidases 8 and 9 on macrophage maturation

18:00h-19:00h – IPS Members Business Meeting/Election

Thrusday, October 30^th:

9:00 – 9:05h – Chair: Anthony O’Donoghue, University of California in San Diego (UCSD), USA

9:05 – 10:00h – Plenary Lecture

Matthew Bogyo, Stanford University, USA

30 years of covalent protease probes: Where are they now?

10:00-10:25h – Coffee Break

10:30h-11:45h – Session 9: Proteolysis in Pathogens and Toxins, and in Host-Pathogen Interactions

Chair: Jan Potempa, Jagiellonian University, Poland

10:30h-10:55h – Solange Serrano, Instituto Butantan, Brazil

Proteolysis in Bothrops snake envenomation

10:55h-11:20h – Hayley Newton, Monash University, Australia

Coxiella burnetii and Cathepsin B

11:20h -11:45h – Jeremy Mottram, University of York, UK

Proteolysis and life cycle progression in the Leishmania parasite

11:45h-12:00h – Oral presentation 18: Charaf Benarafa -University of Bern, Switzerland

Neutrophil serine proteases process SARS-CoV-2 spike and reduce viral entry and inflammation

12:00h- 12:15h – Oral presentation 19: Cornelius Taabazuing -University of Pennsylvania, USA

Human noncanonical inflammasomes activate caspase-3 to limit intracellular Salmonella replication

12:15h- 14:00h – Lunch

14:00h-15:40h – Session 10: Proteolysis in Post-Translational Modifications and targeted degradation

Chair: Henry Maun, Genentech, USA

14:00h-14:25h – Malte Gersch, Chemical genomics Center Max Planck Society, Germany

How Ubiquitin-specific proteases decode Ubiquitin signaling

14:25h-14:50h – Wioletta Rut, Wroclaw University, Poland

Ubiquitin-like protein-based chemical tools for selective targeting of deconjugation enzymes

14:50h-15:00h – Gilles Lalmanach, Université François Rabelais, France

ProteoCure: a structuring research network dedicated to proteostasis and proteolysis

15:00h-15:10h – Introduction of the Ulrich auf dem Keller Young Investigator Award

Chair: Ruth Geiss-Friedlander, IPS President

15:10h-15:35h – Awardee: Laura Edgington-Mitchell, University of Melbourne, Australia

Beyond the lysosome: Unveiling new roles of canonically lysosomal proteases

15:30h-16:00h – Coffee break

16:00h-16:05h – Chair: Marcin Drag, Wroclaw University of Science and Technology, Poland

Introduction of Lifetime Achievement Awardee

16:05h-16:45h – Lifetime Achievement Award Lecture 1

Luiz Juliano Neto, UNIFESP, Brazil

Activation of heparinase by Kallikrein-Related Peptidase -5 (KLK-5)

16:45h-16:50h – Chair: Jeanne Hardy, University of Massachusetts Amherst, USA

Introduction of Lifetime Achievement Awardee

16:50h -17:30h – Lifetime Achievement Award Lecture 2

Bob Lazarus, Genentech, USA

My Adventures with Proteases and the People Who Study Them: Something Old……and Something New

17:30-18:00h: Closing Ceremony: IPS 25^th anniversary – IPS in the Future: 2025 and beyond

Poster Awards / Travel Awards; IPS 2027 Venue and Closing Remarks

19:00h: Depart to Banquet Dinner (casual)