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WE WILL HAVE A LIMITED NUMBER OF PARTICIPANTS, REGISTER EARLY TO GUARANTEE YOUR SPOT.
Registration fee includes access to the event for 5 days, online abstract book, coffee break, lunch, opening reception.
If you wish to book transport by bus Rio-Buzios-Rio, find the link to book your tickets in the registration page below
Find the link to book the room at Atlântico Hotel in the registration page below
REGISTER NOW, AND SUBMIT YOUR ABSTRACT AT ANY TIME UNTIL SEPTEMBER 15th
IPS members
R$ 3.600,00
Non-members
R$ 4.700,00
Membership/2Y
US$ 150
IPS members
R$ 3.500,00
Non-members
R$ 3.500,00
Membership/2Y
US$150,00
IPS members
R$ 2.500,00
Non-members
R$ 2.900,00
Membership/2Y
US$ 50
IPS members
R$ 1.500,00
Non-members
R$ 1.500,00
Membership/2Y
US$ 50
IPS members
Contact us
Non-members
Contact us
Rio de Janeiro
https://www.grayline.com/brazil/things-to-do-in-rio-de-janeiro/
Things to do:
Sugar Loaf
Corcovado (Christ)
Ipanema Beach
Botanical Garden
and much more
Find the perfect stay:
Copacabana (Posto 6)
Fairmont Rio de Janeiro
Orla Hotel
Copacabana Praia Hotel
Atlantis Copacabana Hotel
Bossa Nova Hotel
Arena Ipanema Hotel
Arpoador Inn
Fasano Ipanema
Informations:
🌍 Manaus Tours – Explore the Amazon with expert guides.
Informations:
🏞️ JDS Turismo | Instagram
🏞️ JoiceTur | Instagram
São Paulo
Hotel Grand Mercure Sao_Paulo Ibirapuera-Sao_Paulo_State_of_Sao_Paulo.html
Things to do:
IPS2025 will take place in the Hotel Atlântico Búzios, which is conveniently located in the central area of Búzios, with easy access to restaurants, shops, transport to beaches and local accommodations. The venue is equipped with conference rooms, areas for poster presentations and a foyer where people can interact and have discussions.
For those who wish to stay at The Atlântico hotel, it has 172 comfortable rooms, swimming pool, gym and bar among other amenities. For more on Hotel Atlântico Búzios, access: https://www.atlanticobuzios.com.br/
IPS2025 has secured a promotional price for attendees during the 5 days of the conference. To book a room in the Hotel Atlântico, go to the registration page. Only 110 double rooms are available at the special rate, so be sure to book early to guarantee a room.
Búzios has a tropical climate and temperatures tend to vary between 21-27 °C in the month of October. Ocean breezes are common all year round but are more frequent and stronger during the winter. It is located 173 km east of the City of Rio de Janeiro, with approximately 40,000 inhabitants. Originally, a small remote fishermen village, Búzios remained almost unknown until 1964, when the French actress Brigitte Bardot visited the village and, enchanted by its natural beauties, announced it to the world. Since then, the town grew, first as a prime destination for Rio’s high society and eventually growing into an international tourist destination. Today, Búzios is a worldwide tourist site, receiving annually 670,000 Brazilian visitors and 320,000 international visitors. To experience its charm, just walk along the vibrant Rua das Pedras, full of shops, restaurants, bars, cafes and galleries.
For more information on the tourist attractions in Búzios, access:
https://turismo.buzios.rj.gov.br/pontos-turisticos/ and
https://brazilbeachtravel.com/blog/travel-buzios/buzios
At IPS, we understand that attending conferences and other events related to research can be expensive. We offer Travel Awards to IPS members in training. These grants can help cover the cost of transportation, lodging, and other expenses associated with attending conferences, workshops, and other events.
Who can apply? IPS members in training (master and PhD students and post-docs up to 3 years after obtaining the PhD).
How to apply? Link on the IPS home page https://www.protease.org/
When to apply? Until August 2nd 2025?
Criteria? Presentation in the meeting either as a poster or a selected talk (based on the abstract).
Note: The travel award recipient must be present throughout the meeting to be eligible of the award.
SCIENTIFIC PROGRAM
Sunday, October 26th:
16:00h-18:00h – Registration
18:00h- 18:30h – Snacks and coffee
18:30h-18:55h – Welcome and Opening Ceremony (IPS 25th anniversary) –
IPS Legacy 1999-2025
18:55h-19:00h – Chair: Christopher Overall – Introduction of Opening Lecture
19:00h-20:00h – Opening Lecture
Charles Craik, University of California in San Francisco, USA
Achieving the Potential of Conditionally Activated Therapeutics
20:00h-20:10h Sponsor hour: Instituto Butantan -São Paulo, Brazil
20:10h-22:10h – Welcome reception
Monday, October 27th:
9:00h-9:05h – Chair: Ruth Geiss-Friedlander, University of Freiburg, Germany
9:05h-10:00h – Plenary lecture
Michael H. Glickman, Technion – Israel Institute of Technology, Haifa
The Proteasome – A Multi-Catalytic Protease
10:00-10:25h – Coffee Break
10:30h-11:45h – Session 1: Proteases in Neurobiology and Ageing
Chair: Eiichiro Nishi, Shiga University of Medical Science, Japan
10:30h-10:55h – Natalie Sims, St Vincent’s Institute Melbourne, Australia
Lysosomal proteases in the osteocyte network: controlling bone composition from within?
10:55h-11:20h – Taisuke Tomita, University of Tokyo, Japan
Enhanced proteolytic degradation of amyloids by photo-oxygenation as novel therapeutic strategy for neurodegenerative diseases
11:20h -11:45h – Dieter Bromme, University of British Columbia, Canada
The Cis/Transpeptidase Activity of Cathepsins: The missing link in understanding neoantigens in autoimmunity?
11:45h-12:00h – Oral presentation 1: Danieli Ferrari – University of British Columbia, Canada
Granzyme B deficiency enhances myelin repair and locomotor recovery after spinal cord injury
12:00h- 12:15h – Oral presentation 2: Jonathan Coene – Katholieke Universiteit Leuven, Belgium
Noval Legumain Activity-Based Probes
12:15h- 14:00h – Lunch
14:00h- 15:40h – Session 2: Targeting Proteolysis for Therapeutic Intervention
Chair: Marcin Drag, Wroclaw University of Science and Technology, Poland
14:00h-14:25h – Rama Khokha, University of Toronto, Canada
Title to be announced
14:25h-14:50h – Henry Maun, Genentech, USA
Complete inhibition of β–tryptase by tetramer dissociation and active site allostery due to a single antibody residue
14:50h-15:15h – Manuel Saldivia, Novartis, USA
Drugging the Degrader: Discovery of Parasite-Selective Proteasome Inhibitors
15:15h-15:30h – Oral presentation 3: David Granville – University of British Columbia, Canada
Multi-omic analyses reveals new roles for Granzyme K in psoriasis
15:30h-15:45h – Oral presentation 4: James W Janetka – Washington University, USA
Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1
15:45h-16:10h – Coffee break
16:15h-18:05h – Session 3: Structural Insights into Protease Function
Chair: Kvido Strisovsky, Institute of Organic Chemistry and Biochemistry, Czech Republic
16:15h – 16:40h – Joanne Lemieux, University of Alberta, Canada
Protease-targeted inhibition to address the global AMR threat in gram-negative pathogens
16:40h -17:05h – Hans Brandstetter, University of Salzburg, Austria
Exciting exosites: principles of allosteric activity tuning in cysteine and metalloproteases
17:05 h -17:30h – Jonas Emsley, University of Nottingham, UK
Decoding Contact System Assembly: Structural Mechanisms of Protease Activation and Regulation
17:30h – 17:45h – Oral presentation 5: Irina Bezsonova – Dana Farber Cancer Institute, USA
Unlocking the Puzzle: NMR Spectroscopy Unravels the Mechanism of USP7 Auto-Regulation
17:45h – 18:00h – Oral presentation 6: Jan Konvalinka – Institute of Biotechnology, Czech Republic
Structural characterization of peptidomimetics targeting fibroblast activation protein
18:00-19:30h – Poster Session 1
Tuesday, October 28th:
9:00h-9:05h – Chair: Catherine Moali, CNRS, France
9:05h-10:00h – Plenary Lecture
Irit Sagi, The Weizmann Institute of Science, Israel
Long-Lived Nascent proteolytic ECM Damage Imprints (EDI) impact Tissue Regeneration and Perpetuate Chronic Disease
10:00-10:25h – Coffee Break
10:30h-11:45h – Session 4: Proteolysis in Cellular Homeostasis and Cancer
Chair: Klaudia Brix, Constructor University, Germany
10:30h-10:55h – William W Bachovchin, Tufts University, USA
Determinants of optimal precision targeting of chemotherapeutics to tumors using FAP-activated prodrugs
10:55h-11:20h – Thomas Reinheckel, University of Freiburg, Germany
Functional and molecular links between methionine aminopeptidase 1 (Metap1) and the oncogenic PI3K-pathway in breast cancer
11:20h-11:35h – Oral presentation 7: Nabil G. Seidah –IRCM, Canada
The complementary and synergistic roles of the proprotein convertases PCSK7 and PCSK9 in health and disease
11:20h-11:50h – Oral presentation 8: Lisa Munter – McGill University, Canada
Depletion of the rhomboid protease RHBDL4 increases survival in a mouse model of breast cancer
11:50h-12:05h – Oral presentation 9: Samuel Zolg – University of Freiburg, Germany
An interplay between proteases: DPP9 as a regulator of non-lysosomal cathepsins
12:05h-12:20h – Oral presentation 10: Katiuchia U. Sales – University of São Paulo/Ribeirão Preto, Brazil
Exploring the KLK5–KLK14 Axis in Squamous Cell Carcinogenesis
12:15h-14:00h – Lunch
14:00h-15:15h – Session 5: Emerging Techniques in Proteolysis Research
Chair: Jan Kovalinka, Institute of Organic Chemistry and Biochemistry, Czech Republic
14:00h-14:25h – Anthony O’Donoghue, University of California in San Diego (UCSD), USA
Chemical Decoupling: A Novel Strategy for Functional Profiling of Individual Proteasome Subunits
14:25h-14:50h – Konstantinos Kalogeropoulos, Technical University of Denmark
End-to-end workflows for global analysis of protease activity
14:50h-15:15h – Galia Blum, The Hebrew University of Jerusalem, Israel
Novel cathepsin inhibitors for disease management
15:15h-15:30h – Margaux M. Pinney, University of California, Berkeley, USA
High-throughput mechanistic protease enzymology
15:30h-15:45h – Oral presentation 11: Wayne Denis Monteiro – Johns Hopkins University, USA
Protease Substrate Profiling using Molecular Indexing of Proteins by Self-Assembly
15:45h-16:10h – Coffee break
16:15h-18:00 h – Session 6: Proteolysis in Blood and Cardiac Function
Chair: Lakshmi Wijeyewickrema, La Trobe University Melbourne, Australia)
16:15h – 16:40h – Ze Zheng, Medical College of Wisconsin, USA
Novel functions of tPA in shaping plasma atherogenic lipid profile
16:40h -17:05h – Long-Sheng Song, University of Iowa, USA
Calpain-Mediated Proteolysis of Junctophilin-2 in Heart Failure
17:05 h -17:30h – Alvin Schmaier, Case Western University, USA
Bradykinin is a Proximal Cause of Cerebral Malaria
17:30h – 17:45h – Oral presentation 12: Antoine Dufour – University of Calgary, Canada
Multi-modal omics analysis to unravel the Proteolytic and Non-Proteolytic Roles of Calpain-3 in disease
17:45h – 18:00h – Oral presentation 13: Daniel Sojka – Biology Centre CAS, Czech Republic
Proteolytic Mechanisms in Ticks and Tick-Borne Pathogens: From Biological Insights to Druggable Targets
18:00-19:30h – Poster Session 2
Wednesday, October 29th:
8:00h-9:30h – Special session: Pharmacological Inhibition of Cathepsin C (Dipeptidyl Peptidase 1) in Neutrophil-Mediated Diseases
Chair: Brice Kormaz, INSERM, France
8:00h-8:15h – Brice Korkmaz and Arianna Bordin, INSERM, France
Therapeutic targeting of cathepsin C: from pathophysiology to treatment
8:15h-8:30h – Lada Sabirova, INSERM, France
Consequences of cathepsin C inhibition on neutrophil serine proteases activation
8:30h-8:45h – Liu Baoer, University Hospital Halle (Saale), Germany
Pharmacological inhibition of cathepsin C in preclinical models
8:45h-9:10h – Kuan-Ju Chen, INSMED, USA
Exploring Cathepsin C (DPP1) Inhibition in Preclinical Models of Rheumatoid Arthritis
9:10h-9:35h – Patrick McDonald, INSMED, USA
Impact of CatC/DPP1 on neutrophil functional responses
09:35h-12:15h – Free Time (Boat tour 10:10h-11:40h – optional sign up)
12:15h-14:00h – Lunch
14:00h-15:40h – Session 7: Proteolysis in Cellular Physiology and Signalling
Chair: Gilles Lalmanach, Université François Rabelais, France
14:00h-14:25h – Mark Gorrell, University of Sidney, Australia
Roles of the prolyl oligopeptidases FAP, DPP4 and DPP9 in fibrosis and tumours
14:25h-14:50h – Catherine Moali, CNRS, France
The mini-collagen toolkit sheds new light on the activity of procollagen proteinases
14:50h-15:15h – Katarzyna Groborz – Wroclaw University, Poland
Exploring macrophage activation with a new generation of caspase probes: how much caspase does it take to kill a cell?
15:15h-15:30h – Oral presentation 14: Sabine Hoeppner – University of Augsburg, Germany
Low Cellular Carbohydrate-Levels Induce Expression of Signal-Peptide-Peptidase-Like 3 (SPPL3)
15:30h-15:45h – Oral presentation 15: Fabio Melo – Uppsala University, Sweden
Mast cell tryptase induces nuclear remodeling and reduced growth in breast cancer cells
15:45h-16:10h – Coffee break
16:15h-17:35 h – Session 8: Proteolysis in Immunity
Chair: Antoine Dufour, University of Calgary, Canada
16:15h – 16:40h – Chris Overall, University of British Columbia, Canada
Unconventional Secretion and Activity of SARS-CoV-2 Main Protease (3CLpro) by Caspase and 3CLpro Activation of Gasdermin D Pore Formation
16:40h -17:05h – Natalie Vergnolle, INSERM, France
Mucosal proteases: targets for visceral pain control
17:05 h -17:30h – Nathan Archer, The Johns Hopkins University, USA
Proteases in the progression of the atopic march
17:30h – 17:45h – Oral presentation 16: Marcin Poreba – Wroclaw University, Poland
Development of Protease-Selective Antibody–Drug Conjugates via Peptide Linkers Containing Unnatural Amino Acids
17:45h – 18:00h – Oral presentation 17: Alina Lozan – University of Freiburg, Germany
Differential impact of cytosolic dipeptidyl aminopeptidases 8 and 9 on macrophage maturation
18:00h-19:00h – IPS Members Business Meeting/Election
Thrusday, October 30th:
9:00 – 9:05h – Chair: Anthony O’Donoghue, University of California in San Diego (UCSD), USA
9:05 – 10:00h – Plenary Lecture
Matthew Bogyo, Stanford University, USA
30 years of covalent protease probes: Where are they now?
10:00-10:25h – Coffee Break
10:30h-11:45h – Session 9: Proteolysis in Pathogens and Toxins, and in Host-Pathogen Interactions
Chair: Jan Potempa, Jagiellonian University, Poland
10:30h-10:55h – Solange Serrano, Instituto Butantan, Brazil
Proteolysis in Bothrops snake envenomation
10:55h-11:20h – Hayley Newton, Monash University, Australia
Coxiella burnetii and Cathepsin B
11:20h -11:45h – Jeremy Mottram, University of York, UK
Proteolysis and life cycle progression in the Leishmania parasite
11:45h-12:00h – Oral presentation 18: Charaf Benarafa -University of Bern, Switzerland
Neutrophil serine proteases process SARS-CoV-2 spike and reduce viral entry and inflammation
12:00h- 12:15h – Oral presentation 19: Cornelius Taabazuing -University of Pennsylvania, USA
Human noncanonical inflammasomes activate caspase-3 to limit intracellular Salmonella replication
12:15h- 14:00h – Lunch
14:00h-15:40h – Session 10: Proteolysis in Post-Translational Modifications and targeted degradation
Chair: Henry Maun, Genentech, USA
14:00h-14:25h – Malte Gersch, Chemical genomics Center Max Planck Society, Germany
How Ubiquitin-specific proteases decode Ubiquitin signaling
14:25h-14:50h – Wioletta Rut, Wroclaw University, Poland
Ubiquitin-like protein-based chemical tools for selective targeting of deconjugation enzymes
14:50h-15:00h – Gilles Lalmanach, Université François Rabelais, France
ProteoCure: a structuring research network dedicated to proteostasis and proteolysis
15:00h-15:10h – Introduction of the Ulrich auf dem Keller Young Investigator Award
Chair: Ruth Geiss-Friedlander, IPS President
15:10h-15:35h – Awardee: Laura Edgington-Mitchell, University of Melbourne, Australia
Beyond the lysosome: Unveiling new roles of canonically lysosomal proteases
15:30h-16:00h – Coffee break
16:00h-16:05h – Chair: Marcin Drag, Wroclaw University of Science and Technology, Poland
Introduction of Lifetime Achievement Awardee
16:05h-16:45h – Lifetime Achievement Award Lecture 1
Luiz Juliano Neto, UNIFESP, Brazil
Activation of heparinase by Kallikrein-Related Peptidase -5 (KLK-5)
16:45h-16:50h – Chair: Jeanne Hardy, University of Massachusetts Amherst, USA
Introduction of Lifetime Achievement Awardee
16:50h -17:30h – Lifetime Achievement Award Lecture 2
Bob Lazarus, Genentech, USA
My Adventures with Proteases and the People Who Study Them: Something Old……and Something New
17:30-18:00h: Closing Ceremony: IPS 25th anniversary – IPS in the Future: 2025 and beyond
Poster Awards / Travel Awards; IPS 2027 Venue and Closing Remarks
19:00h: Depart to Banquet Dinner (casual)
The International Proteolysis Society aims to promote knowledge on the role of proteolysis in all aspects of biological and biomedical research, assembling a wide audience of experts and promoting the training of young scientists in the field. The biennial Meeting of IPS brings together the global scientific community working on proteases, their substrates, and inhibitors, and is a must attend event since 1999.
Highlighted themes include: ageing, cancer, protein turnover and degradation, blood, immunity, infections, neurobiology, metabolism, therapeutic targets, structural biology and much more!
The conference will bring together researchers at various career stages and industry representatives across the field of proteolysis. The 5-day event will include the latest developments in basic and translational research involving proteases including cell biology, structure, biochemistry, new therapeutic approaches for human diseases and state of the art technologies.
IPS2025 will represent a key opportunity for interaction across borders and research fields to enhance knowledge in proteolysis in biological and biomedical sciences, providing exciting opportunities for international collaboration.
IPS2025 will be held in the coastal town of Armação dos Búzios, situated in the State of Rio de Janeiro, in Brazil, just 173 km from the international airport of the city of Rio de Janeiro. Búzios is a beautiful tourist village, located in the tropical zone of the South American subcontinent, bathed by the waters of the Atlantic Ocean, with 23 beaches.
VISA REQUIREMENTS: Brazil requires entry visas for citizens of Afghanistan, Algeria, Angola, Australia Bhutan, Cambodia, Canada, Chad, China, Comoros, Cuba, Democratic Republic of Congo, Djibouti, Egypt, Equatorial Guinea, Eritrea, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Haiti, Ivory Coast, India, Iraq, Iran, Jordan, Kazakhstan, Kenya, Kyrgyzstan, Laos, Lesotho, Liberia, Libya, Madagascar, Malawi, Maldives, Mali, Morocco, Mauritania, Mozambique, Nepal, Niger, Nigeria, North Korea, Oman, Pakistan, Republic of Congo, Rwanda, Saudi Arabia, Senegal, Sierra Leone, Somalia, Sri Lanka, Sudan, South Sudan, Taiwan, Tanzania, Togo, Uganda, United States of America, Uzbekistan, Vanuatu, Vietnam, Yemen, Zambia, Zimbabwe.
Please check if you require a visa at:
https://formulario-mre.serpro.gov.br/sci/pages/web/ui/#/servicos-estrangeiros
Be aware that visas may take a few weeks to be issued, so apply early. Note the change in Brazilian Law effective April 10th, 2025 that will also require US, Canadian and Australian citizens to apply for visas prior to entry.
If you need a letter for your visa application, please send a request with your full name to: ipsbrazil2025@gmail.com
We look forward to welcoming you to IPS2025 in Búzios!