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WE WILL HAVE A LIMITED NUMBER OF PARTICIPANTS, REGISTER EARLY TO GUARANTEE YOUR SPOT.

Registration fee includes access to the event for 5 days, online abstract book, coffee break, lunch, opening reception.
If you wish to book transport by bus Rio-Buzios-Rio, find the link to book your tickets in the registration page below 
Find the link to book the room at Atlântico Hotel in the registration page below

REGISTER NOW, AND SUBMIT YOUR ABSTRACT AT ANY TIME UNTIL SEPTEMBER 15th

Academic professional

IPS members

R$ 3.600,00

Non-members

R$ 4.700,00

Membership/2Y

US$ 150

IPS members

R$ 3.500,00

Non-members

R$ 3.500,00

Membership/2Y

US$150,00

IPS members

R$ 2.500,00

Non-members

R$ 2.900,00

Membership/2Y

US$ 50

IPS members

R$ 1.500,00

Non-members

R$ 1.500,00

Membership/2Y

US$ 50

IPS members

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Non-members

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Registration will be open just on site

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Tourism & Accommodation

Rio de Janeiro

https://www.grayline.com/brazil/things-to-do-in-rio-de-janeiro/

Things to do:

Sugar Loaf
Corcovado (Christ)
Ipanema Beach
Botanical Garden
and much more

Find the perfect stay:

 Copacabana (Posto 6)
 Fairmont Rio de Janeiro
 Orla Hotel
 Copacabana Praia Hotel

 Atlantis Copacabana Hotel
 Bossa Nova Hotel
 Arena Ipanema Hotel
 Arpoador Inn
 Fasano Ipanema

  • Manaus & the Amazon Rainforest

Informations:
🌍 Manaus Tours – Explore the Amazon with expert guides.

  • Pantanal Wildlife Adventures

Informations:

🏞️ JDS Turismo | Instagram
🏞️ JoiceTur | Instagram

São Paulo

Hotel Grand Mercure Sao_Paulo Ibirapuera-Sao_Paulo_State_of_Sao_Paulo.html

 

Things to do:

  • Ibirapuera Park
    A vast urban park offering green spaces, museums, and cultural institutions. 
  • Paulista Avenue
    The city’s main thoroughfare, lined with cultural centers, shops, and restaurants. 
  • Pinacoteca do Estado de São Paulo
    One of Brazil’s most important art museums, showcasing a vast collection of Brazilian art. 
  • Municipal Market of São Paulo (Mercadão)
    A historic market known for its diverse food stalls and the famous mortadella sandwich.
  • Liberdade District
    The heart of the Japanese community in São Paulo, offering unique cultural experiences and cuisine.

Venue

IPS2025 will take place in the Hotel Atlântico Búzios, which is conveniently located in the central area of Búzios, with easy access to restaurants, shops, transport to beaches and local accommodations. The venue is equipped with conference rooms, areas for poster presentations and a foyer where people can interact and have discussions.

For those who wish to stay at The Atlântico hotel, it has 172 comfortable rooms, swimming pool, gym and bar among other amenities. For more on Hotel Atlântico Búzios, access: https://www.atlanticobuzios.com.br/

IPS2025 has secured a promotional price for attendees during the 5 days of the conference. To book a room in the Hotel Atlântico, go to the registration page. Only 110 double rooms are available at the special rate, so be sure to book early to guarantee a room.

Búzios has a tropical climate and temperatures tend to vary between 21-27 °C in the month of October. Ocean breezes are common all year round but are more frequent and stronger during the winter. It is located 173 km east of the City of Rio de Janeiro, with approximately 40,000 inhabitants. Originally, a small remote fishermen village, Búzios remained almost unknown until 1964, when the French actress Brigitte Bardot visited the village and, enchanted by its natural beauties, announced it to the world. Since then, the town grew, first as a prime destination for Rio’s high society and eventually growing into an international tourist destination. Today, Búzios is a worldwide tourist site, receiving annually 670,000 Brazilian visitors and 320,000 international visitors. To experience its charm, just walk along the vibrant Rua das Pedras, full of shops, restaurants, bars, cafes and galleries.

For more information on the tourist attractions in Búzios, access: 
https://turismo.buzios.rj.gov.br/pontos-turisticos/ and
https://brazilbeachtravel.com/blog/travel-buzios/buzios

Travel Awards

At IPS, we understand that attending conferences and other events related to research can be expensive. We offer Travel Awards to IPS members in training. These grants can help cover the cost of transportation, lodging, and other expenses associated with attending conferences, workshops, and other events. 

Who can apply? IPS members in training (master and PhD students and post-docs up to 3 years after obtaining the PhD). 

How to apply? Link on the IPS home page https://www.protease.org/

When to apply? Until August 2nd 2025?

Criteria? Presentation in the meeting either as a poster or a selected talk (based on the abstract).

Note: The travel award recipient must be present throughout the meeting to be eligible of the award. 

CHECK LATER FOR UPDATES IN THE FULL PROGRAM

SCIENTIFIC PROGRAM

Sunday, October 26th:

16:00h-18:00h – Registration

18:00h- 18:30h – Snacks and coffee

18:30h-18:55h – Welcome and Opening Ceremony (IPS 25th anniversary) –

IPS Legacy 1999-2025

18:55h-19:00h – Chair: Christopher Overall – Introduction of Opening Lecture

19:00h-20:00h – Opening Lecture

Charles Craik, University of California in San Francisco, USA

Achieving the Potential of Conditionally Activated Therapeutics

 

20:00h-20:10h Sponsor hour:  Instituto Butantan -São Paulo, Brazil

 

20:10h-22:10h – Welcome reception

 

Monday, October 27th:

9:00h-9:05h – Chair: Ruth Geiss-Friedlander, University of Freiburg, Germany

9:05h-10:00h – Plenary lecture

Michael H. Glickman, Technion – Israel Institute of Technology, Haifa

The Proteasome – A Multi-Catalytic Protease

 

10:00-10:25h – Coffee Break

10:30h-11:45h – Session 1: Proteases in Neurobiology and Ageing

Chair: Eiichiro Nishi, Shiga University of Medical Science, Japan

10:30h-10:55h – Natalie Sims, St Vincent’s Institute Melbourne, Australia

Lysosomal proteases in the osteocyte network: controlling bone composition from within?

10:55h-11:20h – Taisuke Tomita, University of Tokyo, Japan

Enhanced proteolytic degradation of amyloids by photo-oxygenation as novel therapeutic strategy for neurodegenerative diseases

11:20h -11:45h – Dieter Bromme, University of British Columbia, Canada

The Cis/Transpeptidase Activity of Cathepsins: The missing link in understanding neoantigens in autoimmunity?

11:45h-12:00h – Oral presentation 1: Danieli Ferrari – University of British Columbia, Canada

Granzyme B deficiency enhances myelin repair and locomotor recovery after spinal cord injury  

12:00h- 12:15h – Oral presentation 2: Jonathan Coene – Katholieke Universiteit Leuven, Belgium

Noval Legumain Activity-Based Probes  

12:15h- 14:00h – Lunch

14:00h- 15:40h – Session 2: Targeting Proteolysis for Therapeutic Intervention

Chair: Marcin Drag, Wroclaw University of Science and Technology, Poland

14:00h-14:25h – Rama Khokha, University of Toronto, Canada

Title to be announced

14:25h-14:50h – Henry Maun, Genentech, USA

Complete inhibition of β–tryptase by tetramer dissociation and active site allostery due to a single antibody residue

14:50h-15:15h – Manuel Saldivia, Novartis, USA

Drugging the Degrader: Discovery of Parasite-Selective Proteasome Inhibitors

15:15h-15:30h – Oral presentation 3: David Granville – University of British Columbia, Canada

Multi-omic analyses reveals new roles for Granzyme K in psoriasis

15:30h-15:45h – Oral presentation 4:   James W Janetka – Washington University, USA

 

Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1

 

15:45h-16:10h – Coffee break

16:15h-18:05h – Session 3: Structural Insights into Protease Function

Chair: Kvido Strisovsky, Institute of Organic Chemistry and Biochemistry, Czech Republic

16:15h – 16:40h – Joanne Lemieux, University of Alberta, Canada

Protease-targeted inhibition to address the global AMR threat in gram-negative pathogens

16:40h -17:05h – Hans Brandstetter, University of Salzburg, Austria

Exciting exosites: principles of allosteric activity tuning in cysteine and metalloproteases

17:05 h -17:30h – Jonas Emsley, University of Nottingham, UK

Decoding Contact System Assembly: Structural Mechanisms of Protease Activation and Regulation

17:30h – 17:45h – Oral presentation 5: Irina Bezsonova – Dana Farber Cancer Institute, USA

Unlocking the Puzzle: NMR Spectroscopy Unravels the Mechanism of USP7 Auto-Regulation

17:45h – 18:00h – Oral presentation 6: Jan Konvalinka – Institute of Biotechnology, Czech Republic

Structural characterization of peptidomimetics targeting fibroblast activation protein

18:00-19:30h – Poster Session 1

 

Tuesday, October 28th:

9:00h-9:05h – Chair: Catherine Moali, CNRS, France

9:05h-10:00h – Plenary Lecture

Irit Sagi, The Weizmann Institute of Science, Israel

Long-Lived Nascent proteolytic ECM Damage Imprints (EDI) impact Tissue Regeneration and Perpetuate Chronic Disease

10:00-10:25h – Coffee Break

10:30h-11:45h – Session 4: Proteolysis in Cellular Homeostasis and Cancer

Chair: Klaudia Brix, Constructor University, Germany

10:30h-10:55h – William W Bachovchin, Tufts University, USA

Determinants of optimal precision targeting of chemotherapeutics to tumors using FAP-activated prodrugs

10:55h-11:20h – Thomas Reinheckel, University of Freiburg, Germany

Functional and molecular links between methionine aminopeptidase 1 (Metap1) and the oncogenic PI3K-pathway in breast cancer

11:20h-11:35h – Oral presentation 7: Nabil G. Seidah –IRCM, Canada

The complementary and synergistic roles of the proprotein convertases PCSK7 and PCSK9 in health and disease

11:20h-11:50h – Oral presentation 8: Lisa Munter – McGill University, Canada

Depletion of the rhomboid protease RHBDL4 increases survival in a mouse model of breast cancer

11:50h-12:05h – Oral presentation 9: Samuel Zolg – University of Freiburg, Germany

An interplay between proteases: DPP9 as a regulator of non-lysosomal cathepsins

12:05h-12:20h – Oral presentation 10:  Katiuchia U. Sales – University of São Paulo/Ribeirão Preto, Brazil

Exploring the KLK5–KLK14 Axis in Squamous Cell Carcinogenesis

12:15h-14:00h – Lunch

14:00h-15:15h – Session 5: Emerging Techniques in Proteolysis Research

Chair: Jan Kovalinka, Institute of Organic Chemistry and Biochemistry, Czech Republic

14:00h-14:25h – Anthony O’Donoghue, University of California in San Diego (UCSD), USA

Chemical Decoupling: A Novel Strategy for Functional Profiling of Individual Proteasome Subunits

14:25h-14:50h – Konstantinos Kalogeropoulos, Technical University of Denmark

End-to-end workflows for global analysis of protease activity

14:50h-15:15h – Galia Blum, The Hebrew University of Jerusalem, Israel

Novel cathepsin inhibitors for disease management

15:15h-15:30h – Margaux M. Pinney, University of California, Berkeley, USA

High-throughput mechanistic protease enzymology

15:30h-15:45h – Oral presentation 11: Wayne Denis Monteiro – Johns Hopkins University, USA

Protease Substrate Profiling using Molecular Indexing of Proteins by Self-Assembly

15:45h-16:10h – Coffee break

 

16:15h-18:00 h – Session 6: Proteolysis in Blood and Cardiac Function

Chair: Lakshmi Wijeyewickrema, La Trobe University Melbourne, Australia)

16:15h – 16:40h – Ze Zheng, Medical College of Wisconsin, USA

Novel functions of tPA in shaping plasma atherogenic lipid profile

16:40h -17:05h – Long-Sheng Song, University of Iowa, USA

Calpain-Mediated Proteolysis of Junctophilin-2 in Heart Failure

17:05 h -17:30h – Alvin Schmaier, Case Western University, USA

Bradykinin is a Proximal Cause of Cerebral Malaria

17:30h – 17:45h – Oral presentation 12: Antoine Dufour – University of Calgary, Canada

Multi-modal omics analysis to unravel the Proteolytic and Non-Proteolytic Roles of Calpain-3 in disease

17:45h – 18:00h – Oral presentation 13: Daniel Sojka – Biology Centre CAS, Czech Republic

Proteolytic Mechanisms in Ticks and Tick-Borne Pathogens: From Biological Insights to Druggable Targets

 

18:00-19:30h – Poster Session 2

 

Wednesday, October 29th:

8:00h-9:30h – Special session: Pharmacological Inhibition of Cathepsin C (Dipeptidyl Peptidase 1) in Neutrophil-Mediated Diseases

Chair: Brice Kormaz, INSERM, France

8:00h-8:15h – Brice Korkmaz and Arianna Bordin, INSERM, France

Therapeutic targeting of cathepsin C: from pathophysiology to treatment

 

8:15h-8:30h – Lada Sabirova, INSERM, France

Consequences of cathepsin C inhibition on neutrophil serine proteases activation

 

8:30h-8:45h – Liu Baoer, University Hospital Halle (Saale), Germany

Pharmacological inhibition of cathepsin C in preclinical models

 

8:45h-9:10h – Kuan-Ju Chen, INSMED, USA

Exploring Cathepsin C (DPP1) Inhibition in Preclinical Models of Rheumatoid Arthritis

 

9:10h-9:35h – Patrick McDonald, INSMED, USA

Impact of CatC/DPP1 on neutrophil functional responses

 

09:35h-12:15h – Free Time (Boat tour 10:10h-11:40h – optional sign up)

12:15h-14:00h – Lunch

 

14:00h-15:40h – Session 7: Proteolysis in Cellular Physiology and Signalling

Chair: Gilles Lalmanach, Université François Rabelais, France

14:00h-14:25h – Mark Gorrell, University of Sidney, Australia

Roles of the prolyl oligopeptidases FAP, DPP4 and DPP9 in fibrosis and tumours

14:25h-14:50h – Catherine Moali, CNRS, France

The mini-collagen toolkit sheds new light on the activity of procollagen proteinases

14:50h-15:15h – Katarzyna Groborz – Wroclaw University, Poland

Exploring macrophage activation with a new generation of caspase probes: how much caspase does it take to kill a cell?

15:15h-15:30h – Oral presentation 14: Sabine Hoeppner – University of Augsburg, Germany

Low Cellular Carbohydrate-Levels Induce Expression of Signal-Peptide-Peptidase-Like 3 (SPPL3)

15:30h-15:45h – Oral presentation 15: Fabio Melo – Uppsala University, Sweden

Mast cell tryptase induces nuclear remodeling and reduced growth in breast cancer cells

 

15:45h-16:10h – Coffee break

16:15h-17:35 h – Session 8: Proteolysis in Immunity

Chair: Antoine Dufour, University of Calgary, Canada

16:15h – 16:40h – Chris Overall, University of British Columbia, Canada

Unconventional Secretion and Activity of SARS-CoV-2 Main Protease (3CLpro) by Caspase and 3CLpro Activation of Gasdermin D Pore Formation

16:40h -17:05h – Natalie Vergnolle, INSERM, France

Mucosal proteases: targets for visceral pain control

17:05 h -17:30h – Nathan Archer, The Johns Hopkins University, USA

Proteases in the progression of the atopic march

17:30h – 17:45h – Oral presentation 16: Marcin Poreba – Wroclaw University, Poland

Development of Protease-Selective Antibody–Drug Conjugates via Peptide Linkers Containing Unnatural Amino Acids

17:45h – 18:00h – Oral presentation 17: Alina Lozan – University of Freiburg, Germany

Differential impact of cytosolic dipeptidyl aminopeptidases 8 and 9 on macrophage maturation

 

18:00h-19:00h – IPS Members Business Meeting/Election

 

Thrusday, October 30th:

9:00 – 9:05h – Chair: Anthony O’Donoghue, University of California in San Diego (UCSD), USA

9:05 – 10:00h – Plenary Lecture

Matthew Bogyo, Stanford University, USA

30 years of covalent protease probes: Where are they now?

10:00-10:25h – Coffee Break

10:30h-11:45h – Session 9: Proteolysis in Pathogens and Toxins, and in Host-Pathogen Interactions

Chair: Jan Potempa, Jagiellonian University, Poland

10:30h-10:55h – Solange Serrano, Instituto Butantan, Brazil

Proteolysis in Bothrops snake envenomation

10:55h-11:20h – Hayley Newton, Monash University, Australia

Coxiella burnetii and Cathepsin B

11:20h -11:45h – Jeremy Mottram, University of York, UK

Proteolysis and life cycle progression in the Leishmania parasite

11:45h-12:00h – Oral presentation 18: Charaf Benarafa -University of Bern, Switzerland

Neutrophil serine proteases process SARS-CoV-2 spike and reduce viral entry and inflammation

12:00h- 12:15h – Oral presentation 19: Cornelius Taabazuing -University of Pennsylvania, USA

Human noncanonical inflammasomes activate caspase-3 to limit intracellular Salmonella replication

12:15h- 14:00h – Lunch

14:00h-15:40h – Session 10: Proteolysis in Post-Translational Modifications and targeted degradation

Chair: Henry Maun, Genentech, USA

14:00h-14:25h – Malte Gersch, Chemical genomics Center Max Planck Society, Germany

How Ubiquitin-specific proteases decode Ubiquitin signaling

14:25h-14:50h – Wioletta Rut, Wroclaw University, Poland

Ubiquitin-like protein-based chemical tools for selective targeting of deconjugation enzymes

14:50h-15:00h – Gilles Lalmanach, Université François Rabelais, France

ProteoCure: a structuring research network dedicated to proteostasis and proteolysis

15:00h-15:10h – Introduction of the Ulrich auf dem Keller Young Investigator Award

 

Chair: Ruth Geiss-Friedlander, IPS President

 

15:10h-15:35h – Awardee: Laura Edgington-Mitchell, University of Melbourne, Australia

Beyond the lysosome: Unveiling new roles of canonically lysosomal proteases

15:30h-16:00h – Coffee break

16:00h-16:05h – Chair: Marcin Drag, Wroclaw University of Science and Technology, Poland

Introduction of Lifetime Achievement Awardee

16:05h-16:45h – Lifetime Achievement Award Lecture 1

 

Luiz Juliano Neto, UNIFESP, Brazil

Activation of heparinase by Kallikrein-Related Peptidase -5 (KLK-5)

16:45h-16:50h – Chair: Jeanne Hardy, University of Massachusetts Amherst, USA

Introduction of Lifetime Achievement Awardee

16:50h -17:30h – Lifetime Achievement Award Lecture 2

 

Bob Lazarus, Genentech, USA

My Adventures with Proteases and the People Who Study Them: Something Old……and Something New

17:30-18:00h:  Closing Ceremony: IPS 25th anniversary – IPS in the Future: 2025 and beyond

Poster Awards / Travel Awards; IPS 2027 Venue and Closing Remarks

 

19:00h:  Depart to Banquet Dinner (casual)

General Information

The International Proteolysis Society aims to promote knowledge on the role of proteolysis in all aspects of biological and biomedical research, assembling a wide audience of experts and promoting the training of young scientists in the field. The biennial Meeting of IPS brings together the global scientific community working on proteases, their substrates, and inhibitors, and is a must attend event since 1999. 

Highlighted themes include: ageing, cancer, protein turnover and degradation, blood, immunity, infections, neurobiology, metabolism, therapeutic targets, structural biology and much more!

The conference will bring together researchers at various career stages and industry representatives across the field of proteolysis. The 5-day event will include the latest developments in basic and translational research involving proteases including cell biology, structure, biochemistry, new therapeutic approaches for human diseases and state of the art technologies.

IPS2025 will represent a key opportunity for interaction across borders and research fields to enhance knowledge in proteolysis in biological and biomedical sciences, providing exciting opportunities for international collaboration.

IPS2025 will be held in the coastal town of Armação dos Búzios, situated in the State of Rio de Janeiro, in Brazil, just 173 km from the international airport of the city of Rio de Janeiro.  Búzios is a beautiful tourist village, located in the tropical zone of the South American subcontinent, bathed by the waters of the Atlantic Ocean, with 23 beaches. 

VISA REQUIREMENTS: Brazil requires entry visas for citizens of Afghanistan, Algeria, Angola, Australia Bhutan, Cambodia, Canada, Chad, China, Comoros, Cuba, Democratic Republic of Congo, Djibouti, Egypt, Equatorial Guinea, Eritrea, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Haiti, Ivory Coast, India, Iraq, Iran, Jordan, Kazakhstan, Kenya, Kyrgyzstan, Laos, Lesotho, Liberia, Libya, Madagascar, Malawi, Maldives, Mali, Morocco, Mauritania, Mozambique, Nepal, Niger, Nigeria, North Korea, Oman, Pakistan, Republic of Congo, Rwanda, Saudi Arabia, Senegal, Sierra Leone, Somalia, Sri Lanka, Sudan, South Sudan, Taiwan, Tanzania, Togo, Uganda, United States of America, Uzbekistan, Vanuatu, Vietnam, Yemen, Zambia, Zimbabwe. 

Please check if you require a visa at: 
https://formulario-mre.serpro.gov.br/sci/pages/web/ui/#/servicos-estrangeiros 

Be aware that visas may take a few weeks to be issued, so apply early. Note the change in Brazilian Law effective April 10th, 2025 that will also require US, Canadian and Australian citizens to apply for visas prior to entry. 

If you need a letter for your visa application, please send a request with your full name to: ipsbrazil2025@gmail.com 

We look forward to welcoming you to IPS2025 in Búzios!